MGF dosage for a large / giant breed
over 77 lb (35 kg)
The short answer
For a dog weighing over 77 lb (35 kg), the dose of MGF reported in the literature is 80-350 mcg per day, given daily or every other day, over 4-6 weeks. It is studied in this weight class primarily for muscle repair, muscle loss, post-injury recovery. These figures are reported as published and are not recommendations — the dose for an individual dog must be set by a veterinarian who has examined the animal.
Worked examples at specific weights
Calculated from the reported range of 2–5 mcg per kg of body weight.
| Body weight | Calculated dose range | Frequency |
|---|---|---|
| 40 kg (88 lb) | 80–200 mcg | Daily or every other day |
| 50 kg (110 lb) | 100–250 mcg | Daily or every other day |
| 60 kg (132 lb) | 120–300 mcg | Daily or every other day |
For an exact figure at your dog's weight, use the dose calculator.
Typical breeds in this weight class
German Shepherd, Labrador Retriever, Rottweiler, Great Dane, Mastiff and similarly sized dogs generally fall within over 77 lb (35 kg). Weigh your dog rather than estimating — dosing is calculated per kilogram and an estimate that is out by a few kilos changes the figure materially, particularly at the smaller end.
Before dosing at all
⚠ Contraindicated with active cancer
As an IGF-1 family growth factor, MGF promotes cell proliferation. It should not be used in a dog with known or suspected malignancy.
Common questions
How much MGF for a large / giant breed?+
For a dog in the over 77 lb (35 kg) range, the reported dose is 80-350 mcg per day, given daily or every other day, typically for 4-6 weeks. At a representative weight of 45 kg (about 99 lb), that works out to roughly 90–225 mcg per dose. These figures are reported from the source literature and are not recommendations.
How often should a large / giant breed be given MGF?+
Daily or every other day is the reported frequency, over a course of 4-6 weeks. See the cycling guide for how breaks are structured.
Is MGF safe for a large / giant breed?+
MGF is among the least-studied compounds on this site in any species, and there is no canine clinical data at all — the evidence is mechanistic. Its very short half-life means systemic exposure is limited, which is reassuring, but it shares the IGF-1 family contraindication: it should not be used in a dog with known or suspected cancer, and it should not be stacked with IGF-1 LR3.
References
- 1.Goldspink G Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology, 2005. PMID 16174871
Other weight classes: MGF for a small / toy breed, MGF for a medium breed.
Educational information — not veterinary medical advice
Everything on this page is compiled from published peer-reviewed literature for educational and research purposes. It does not establish a veterinarian-client-patient relationship (VCPR) and is not a substitute for veterinary examination and diagnosis. Most compounds described here are investigational or used off-label and are not FDA-approved for these purposes in dogs. Extralabel drug use in animals requires a valid VCPR and the direct supervision of a licensed veterinarian under AMDUCA (21 U.S.C. §360b). Dosing figures are reported as they appear in the source literature and are not recommendations.